DNMT inhibitor, 5-aza-2′-deoxycytidine mitigates di(2-ethylhexyl) phthalate-induced aggravation of psoriasiform inflammation in mice via reduction in global DNA methylation in dermal and peripheral compartments

Author:

Alfardan Ali S.,Nadeem AhmedORCID,Ahmad Sheikh F.,Al-Harbi Naif O.,Alqinyah Mohammad,Attia Sabry M.,El-Sherbeeny Ahmed M.,Al-Harbi Mohammad M.,Al-Shabanah Othman A.,Ibrahim Khalid E.,Alhazzani Khalid,Alanazi Ahmed Z.

Funder

King Saud University

Publisher

Elsevier BV

Reference58 articles.

1. Plasticizer, di(2-ethylhexyl)phthalate (DEHP) enhances cockroach allergen extract-driven airway inflammation by enhancing pulmonary Th2 as well as Th17 immune responses in mice;Alfardan;Environ. Res.,2018

2. Worsening of imiquimod-induced psoriasiform inflammation in mice by environmental pollutant, di-(2-ethylhexyl) phthalate through dysregulation in IL-17A and Nrf2/iNOS signaling in peripheral myeloid and CD4 + T cells;Alfardan;Int. Immunopharmacol.,2024

3. Lck signaling inhibition causes improvement in clinical features of psoriatic inflammation through reduction in inflammatory cytokines in CD4+ T cells in imiquimod mouse model;Al-Harbi;Cell. Immunol.,2022

4. Pathophysiology, clinical presentation, and treatment of psoriasis: a review;Armstrong;J. Am. Med. Assoc.,2020

5. Immune system: an emerging player in mediating effects of endocrine disruptors on metabolic health;Bansal;Endocrinology,2018

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