Prostate Cancer Cell Phenotypes Remain Stable Following PDE5 Inhibition in the Clinically Relevant Range

Author:

Hankey William,Sunkel Benjamin,Yuan Fuwen,He Haiyan,Thomas-Ahner Jennifer M.,Chen Zhong,Clinton Steven K.,Huang Jiaoti,Wang Qianben

Funder

National Institutes of Health

U.S. Department of Defense

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference46 articles.

1. 3′,5'-Cyclic nucleotide phosphodiesterase in tumor cells as potential target for tumor growth inhibition;Drees;Cancer Res.,1993

2. Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A;Arozarena;Cancer Cell,2011

3. Expression and role of phosphodiesterase 5 in human malignant melanoma cell line;Murata;Anticancer Res.,2010

4. Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells;Sarfati;Blood,2003

5. Vardenafil, a clinically available phosphodiesterase inhibitor, potentiates the killing effect of EGCG on CLL cells;Kumazoe;Br. J. Haematol.,2015

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