Overactivated NRF2 induces pseudohypoxia in hepatocellular carcinoma by stabilizing HIF-1α

Author:

Zheng Jie,Kim Su-Jung,Saeidi Soma,Kim Seong Hoon,Fang Xizhu,Lee Yeon-Hwa,Guillen-Quispe Yanymee N.,Ngo Hoang Kieu Chi,Kim Do-Hee,Kim Doojin,Surh Young-JoonORCID

Funder

National Research Foundation of Korea

Publisher

Elsevier BV

Subject

Physiology (medical),Biochemistry

Reference47 articles.

1. The impact of hypoxia in hepatocellular carcinoma metastasis;Wong;Front. Med.,2014

2. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension;Wang;Proc. Natl. Acad. Sci. U. S. A.,1995

3. Hypoxia-modified cancer cell metabolism;Al Tameemi;Front. Cell Dev. Biol.,2019

4. Hydroxylation of HIF-1: oxygen sensing at the molecular level;Semenza;Physiology (Bethesda),2004

5. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity;Mahon;Genes Dev.,2001

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