Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism

Author:

Androutsopoulos Vasilis P.,Tsatsakis Aristeidis M.

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference41 articles.

1. Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1 mediated metabolism;Androutsopoulos;Breast Cancer Res.,2008

2. Bioactivation of the phytoestrogen diosmetin by CYP1 cytochromes P450;Androutsopoulos;Cancer Lett.,2009

3. The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells;Androutsopoulos;J. Nat. Prod.,2009

4. Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 cells, due to CYP1 activation;Androutsopoulos;Oncol. Rep.,2009

5. Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids;Androutsopoulos;Bioorg. Med. Chem.,2011

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