Use of a rat ex-vivo testis culture method to assess toxicity of select known male reproductive toxicants

Author:

Goldstein Keith M.,Seyler David E.,Durand Philippe,Perrard Marie-Hélène,Baker Thomas K.

Publisher

Elsevier BV

Subject

Toxicology

Reference80 articles.

1. Validation of a rat seminiferous tubule culture model as a suitable system for studying toxicant impact on meiosis effect of hexavalent chromium;Geoffroy-Siraudin;Toxicol. Sci.,2010

2. Meiotic differentiation of germinal cells in three-week cultures of whole cell population from rat seminiferous tubules;Hue;Biol. Reprod.,1998

3. The whole meiotic process can occur in vitro in untransformed rat spermatogenic cells;Staub;Exp. Cell Res.,2000

4. Incidence and nature of testicular toxicity findings in pharmaceutical development;Sasaki;Birth Defects Res. B Dev. Reprod. Toxicol.,2011

5. ICH Harmonized Tripartite Guideline S5(R2): Detection of Toxicity to Reproduction for Medicinal Products & Toxicity to Male Fertility (2005).

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