The role of ethyl acrylate induced GSH depletion in the rodent forestomach and its impact on MTD and in vivo genotoxicity in developing an adverse outcome pathway (AOP)

Author:

Ellis-Hutchings R.,Giuliani J.,Hayashi M.,Masumori S.ORCID,McClymont E.L.,Murphy S.ORCID,Wiench K.

Funder

Arkema Inc.

BASF SE

The Dow Chemical Company

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference50 articles.

1. Inflammation and cancer: how hot is the link?;Aggarwal;Biochem. Pharmacol.,2006

2. Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment;Ankley;Environ. Toxicol. Chem.,2010

3. AOP Wiki. Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat). Event 781: AOP 115. https://aopwiki.org/wiki/index.php/Event:781.

4. Application of key events analysis to chemical carcinogens and noncarclnogens;Boobis;Crit. Rev. Food Sci. Nutr.,2009

5. Studies on the chronic oral toxicity of monomeric ethyl acrylate and methyl methacrylate;Borzelleca;Toxicol. Appl. Pharmacol.,1964

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