Pharmacokinetics and efficacy of atropine sulfate/obidoxime chloride co-formulation against VX in a guinea pig model

Author:

Kentrop Jiska,Savransky Vladimir,Klaassen Steven D.,van Groningen Tomas,Bohnert Sara,Cornelissen Alex S.,Cochrane Laura,Barry John,Joosen Marloes J.A.

Funder

OBI

Emergent BioSolutions Inc

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference35 articles.

1. Pharmacokinetic analysis of pralidoxime after its intramuscular injection alone or in combination with atropine-avizafone in healthy volunteers;Abbara;Br. J. Pharmacol.,2010

2. Practical Guide for Medical Management of Chemical Warfare Casualties;OPCW,2019

3. Pharmacokinetics of obidoxime in organophosphate poisoning associated with renal failure;Bentur;Clin. Toxicol.,1993

4. Comparative pharmacokinetics of three oximes in a Guinea pig model and efficacy of combined oxime therapy;Bohnert;Toxicol. Lett.,2020

5. Pharmacokinetics of the acetylcholinesterase oxime reactivator, HI-6, in rhesus monkeys (Macaca mulatta): effect of atropine, diazepam, and methoxyflurane anesthesia;Clement;Biopharm Drug Dispos.,1990

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