Protein kinase B (Akt) blockade inhibits LH/hCG-mediated 17,20-lyase, but not 17α-hydroxylase activity of Cyp17a1 in mouse Leydig cell steroidogenesis

Author:

Paradiso Elia,Lazzaretti Clara,Sperduti Samantha,Melli Beatrice,Trenti Tommaso,Tagliavini Simonetta,Roli Laura,D'Achille Fabio,Beltrán-Frutos Ester,Simoni Manuela,Casarini Livio

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Elsevier BV

Subject

Cell Biology

Reference51 articles.

1. The Lutropin/Choriogonadotropin receptor, A 2002 perspective;Ascoli;Endocr. Rev.,2002

2. Assessing gonadotropin receptor function by resonance energy transfer-based assays;Ayoub;Front. Endocrinol.,2015

3. Repression of cAMP-induced expression of the mouse P450 17 alpha-hydroxylase/C17-20 lyase gene (Cyp17) by androgens;Burgos-Trinidad;Molecular Endocrinology (Baltimore, Md.),1997

4. Steroidogenic cytochrome P450 17A1 structure and function;Burris-Hiday;Mol. Cell. Endocrinol.,2021

5. LH and hCG action on the same receptor results in quantitatively and qualitatively different intracellular signalling;Casarini;PLoS One,2012

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