Protocol for preclinical evaluation of locoregionally delivered CAR T cells in patient-derived xenograft models of brain tumors

Author:

Draper Benjamin,Bowers Chantelle,Vassalou Eleni,Greppi Ailsa,Anderson John,Ahmed Nabil,Taylor Michael D.,Donovan Laura K.ORCID

Publisher

Elsevier BV

Reference5 articles.

1. Locoregional delivery of CAR T-cells to the cerebrospinal fluid as effective therapy for metastatic medulloblastoma and ependymoma;Donovan;Nat. Med.,2020

2. Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors;Muliaditan;Cell Rep. Med.,2021

3. Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis;Schietinger;Immunity,2016

4. In vitro modeling of CD8+ T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40;Wu;Sci. Immunol.,2023

5. Implications of the discovery of brain lymphatic pathways;Iliff;Lancet Neurol.,2015

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