Alpaca-derived nanobody targeting the hydrophobic pocket of the HIV-1 gp41 NHR broadly neutralizes HIV-1 by blocking six-helix bundle formation-Reference-Cited by-同舟云学术

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Alpaca-derived nanobody targeting the hydrophobic pocket of the HIV-1 gp41 NHR broadly neutralizes HIV-1 by blocking six-helix bundle formation

Published:2024 Issue: Volume:7 Page:100263
ISSN:2666-5174
Container-title:Current Research in Microbial Sciences
language:en
Short-container-title:Current Research in Microbial Sciences

Author:

Sun Lujia,Chen Bo,Liu Xianbo,Zhu Yun,Zhang Guangxu,Liang Xiaoxing,Xing Lixiao,Xu Wei,Jiang Shibo^ORCID,Wang Xinling

Funder

Shanghai Municipality Science and Technology Commission

Publisher

Elsevier BV

Reference46 articles.

1. Accurate structure prediction of biomolecular interactions with AlphaFold 3;Abramson;Nature,2024

2. Novel engineered SARS-CoV-2 HR1 trimer exhibits improved potency and broad-spectrum activity against SARS-CoV-2 and its variants;Bi;J. Virol.,2022

3. Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies;Bruun;J. Biol. Chem.,2023

4. Neutralizing antibodies targeting HIV-1 gp41;Caillat;Viruses,2020

5. Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoprotein;Cao;J. Virol.,1993

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