The novel dual-mechanism Kv7 potassium channel/TSPO receptor activator GRT-X is more effective than the Kv7 channel opener retigabine in the 6-Hz refractory seizure mouse model

Author:

Bloms-Funke Petra,Bankstahl Marion,Bankstahl JensORCID,Kneip Christa,Schröder Wolfgang,Löscher Wolfgang

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference80 articles.

1. N-pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy;Amato;ACS Med. Chem. Lett.,2011

2. Australian Public Assessment Report for Retigabine;Australian Government,2013

3. Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models;Bankstahl;Neurotoxicology,2012

4. Pilocarpine-induced epilepsy in mice alters seizure thresholds and the efficacy of antiepileptic drugs in the 6-Hertz psychomotor seizure model;Bankstahl;Epilepsy Res.,2013

5. Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine;Barrese;Clin. Pharmacol.,2010

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