Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome-Reference-Cited by-同舟云学术

Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome

Published:2023-02 Issue: Volume:224 Page:109330
ISSN:0028-3908
Container-title:Neuropharmacology
language:en
Short-container-title:Neuropharmacology

Author:

Ossola Bernardino^ORCID,Rifat Ali,Rowland Anna,Hunter Helen,Drinkall Samuel,Bender Clare,Hamlischer Mayida,Teall Martin,Burley Russell,Barker Daneil F.,Cadwalladr David,Dickson Louise,Lawrence Jason M.K.,Harvey Jenna R.M.,Lizio Marina,Xu Xiao,Kavanagh Edel,Cheung Toni,Sheardown Steve,Lawrence Catherine B.,Harte Michael,Brough David,Madry Christian,Matthews Kim,Doyle Kevin,Page Keith,Powell Justin,Brice Nicola L.,Bürli Roland W.,Carlton Mark B.,Dawson Lee A.

Funder

MRC

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference44 articles.

1. 4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: potent and selective p70S6 kinase inhibitors;Bandarage;Bioorg. Med. Chem. Lett,2009

2. Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE);Barclay;Brain Pathol.,2017

3. Effective knockdown of gene expression in primary microglia with siRNA and magnetic nanoparticles without cell death or inflammation;Carrillo-Jimenez;Front. Cell. Neurosci.,2018

4. Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction;Cheng;Biochem. Pharmacol.,1973

5. Microglia function in the central nervous system during health and neurodegeneration;Colonna;Annu. Rev. Immunol.,2017

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