Inhibitors of sterol synthesis. Chemical synthesis, structure, and biological activities of (25R)-3 beta,26-dihydroxy-5 alpha-cholest-8(14)-en-15-one, a metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one.

Author:

Kim H S,Wilson W K,Needleman D H,Pinkerton F D,Wilson D K,Quiocho F A,Schroepfer G J

Publisher

Elsevier BV

Subject

Cell Biology,Endocrinology,Biochemistry

Reference57 articles.

1. Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols;Schroepfer;J. Biol. Chem.,1977

2. 5a-Cholest-8(14)-en-3β-ol-15-one, a potent inhibitor of sterol synthesis, reduces the levels of activity of enzymes involved in the synthesis and reduction of 3-hydroxy- 3-methylglutaryl coenzyme A in CHO-K1 cells;Miller;Biochem. Internat.,1980

3. 14a-Ethyl-5acholest-7-ene-3β,15a-diol, a potent inhibitor of sterol biosynthesis, has two sites of action in cultured mammalian cells;Pinkerton;J. Biol. Chem.,1982

4. Inhibitors of sterol synthesis. Studies of the metabolism of 5a-cholest-8(14)-en-3β-ol-15-one in Chinese hamster ovary cells and its effects on activities of early enzymes in cholesterol biosynthesis;Pajewski;Chem. Phys. Lipids.,1988

5. Inhibitors of sterol synthesis. Dietary administration of 5a-cholest-8(14)-en-3β-ol-15- one inhibits the intestinal absorption of cholesterol;Schroepfer;Biochem. Biophys. Res. Commun.,1987

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