Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease

Author:

Dagar SunayanaORCID,Sharma Manish,Tsaprailis GeorgeORCID,Tapia Catherina Scharager,Crynen GogceORCID,Joshi Preksha SandipkumarORCID,Shahani NeelamORCID,Subramaniam Srinivasa

Funder

NINDS

Publisher

Elsevier BV

Reference83 articles.

1. Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain;Sorbi;Ann. Neurol.,1983

2. Evidence for a defect in NADH: ubiquinone oxidoreductase (complex I) in Huntington's disease;Parker;Neurology,1990

3. Mitochondrial defect in Huntington's disease caudate nucleus;Gu;Ann. Neurol.,1996

4. Complex I defect in muscle from patients with Huntington's disease;Arenas;Ann. Neurol.,1998

5. Dysfunctional mitochondrial respiration in the striatum of the Huntington's disease transgenic R6/2 mouse model;Aidt;PLoS Curr.,2013

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