Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

Author:

Kappos Ludwig,Gold Ralf,Miller David H,MacManus David G,Havrdova Eva,Limmroth Volker,Polman Chris H,Schmierer Klaus,Yousry Tarek A,Yang Minhua,Eraksoy Mefkûre,Meluzinova Eva,Rektor Ivan,Dawson Katherine T,Sandrock Alfred W,O'Neill Gilmore N

Publisher

Elsevier BV

Subject

General Medicine

Reference36 articles.

1. Activation of Nrf2 and modulation of disease progression in EAE models by BG00012 (dimethyl fumarate) suggests a novel mechanism of action combining anti-inflammatory and neuroprotective modalities;Lukashev;Mult Scler,2007

2. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements;Itoh;Biochem Biophys Res Commun,1997

3. Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes;Venugopal;Oncogene,1998

4. Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression;Chen;Am J Physiol Heart Circ Physiol,2006

5. Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2;Calabrese;J Neurosci Res,2005

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