Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK

Author:

Bloom Chloe I,Drake Thomas M,Docherty Annemarie B,Lipworth Brian J,Johnston Sebastian L,Nguyen-Van-Tam Jonathan S,Carson Gail,Dunning Jake,Harrison Ewen M,Baillie J Kenneth,Semple Malcolm G,Cullinan Paul,Openshaw Peter J M,Alex Beatrice,Bach Benjamin,Barclay Wendy S,Bogaert Debby,Chand Meera,Cooke Graham S,Filipe Ana da,Fletcher Tom,Green Christoper A,Harrison Ewen M,Hiscox Julian A,Ho Antonia Ying,Horby Peter W,Ijaz Samreen,Khoo Saye,Klenerman Paul,Law Andrew,Lim Wei Shen,Mentzer Alexander J,Merson Laura,Meynert Alison M,Noursadeghi Mahdad,Moore Shona C,Palmarini Massimo,Paxton William A,Pollakis Georgios,Price Nicholas,Rambaut Andrew,Robertson David L,Russell Clark D,Sancho-Shimizu Vanessa,Scott Janet T,Silva Thushan de,Sigfrid Louise,Solomon Tom,Sriskandan Shiranee,Stuart David,Summers Charlotte,Tedder Richard S,Thomson Emma C,Thompson AA Roger,Thwaites Ryan S,Turtle Lance CW,Zambon Maria,Hardwick Hayley,Donohue Chloe,Lyons Ruth,Griffiths Fiona,Oosthuyzen Wilna,Norman Lisa,Pius Riinu,Fairfield Cameron J,Knight Stephen R,Mclean Kenneth A,Murphy Derek,Shaw Catherine A,Dalton Jo,Girvan Michelle,Saviciute Egle,Roberts Stephanie,Harrison Janet,Marsh Laura,Connor Marie,Halpin Sophie,Jackson Clare,Gamble Carrol,Leeming Gary,Law Andrew,Wham Murray,Clohisey Sara,Hendry Ross,Scott-Brown James,Greenhalf William,Shaw Victoria,McDonald Sara,Keating Seán,Ahmed Katie A.,Armstrong Jane A,Ashworth Milton,Asiimwe Innocent G,Bakshi Siddharth,Barlow Samantha L,Booth Laura,Brennan Benjamin,Bullock Katie,Catterall Benjamin WA,Clark Jordan J,Clarke Emily A,Cole Sarah,Cooper Louise,Cox Helen,Davis Christopher,Dincarslan Oslem,Dunn Chris,Dyer Philip,Elliott Angela,Evans Anthony,Finch Lorna,Fisher Lewis WS,Foster Terry,Garcia-Dorival Isabel,Greenhalf William,Gunning Philip,Hartley Catherine,Jensen Rebecca L,Jones Christopher B,Jones Trevor R,Khandaker Shadia,King Katharine,Kiy Robyn T.,Koukorava Chrysa,Lake Annette,Lant Suzannah,Latawiec Diane,Lavelle-Langham Lara,Lefteri Daniella,Lett Lauren,Livoti Lucia A,Mancini Maria,McDonald Sarah,McEvoy Laurence,McLauchlan John,Metelmann Soeren,Miah Nahida S,Middleton Joanna,Mitchell Joyce,Moore Shona C,Murphy Ellen G,Penrice-Randal Rebekah,Pilgrim Jack,Prince Tessa,Reynolds Will,Ridley P. Matthew,Sales Debby,Shaw Victoria E,Shears Rebecca K,Small Benjamin,Subramaniam Krishanthi S,Szemiel Agnieska,Taggart Aislynn,Tanianis-Hughes Jolanta,Thomas Jordan,Trochu Erwan,Tonder Libby van,Wilcock Eve,Zhang J. Eunice,Flaherty Lisa,Maziere Nicole,Cass Emily,Carracedo Alejandra Doce,Carlucci Nicola,Holmes Anthony,Massey Hannah,Adeniji Kayode,Agranoff Daniel,Agwuh Ken,Ail Dhiraj,Alegria Ana,Angus Brian,Ashish Abdul,Atkinson Dougal,Bari Shahedal,Barlow Gavin,Barnass Stella,Barrett Nicholas,Bassford Christopher,Baxter David,Beadsworth Michael,Bernatoniene Jolanta,Berridge John,Best Nicola,Bothma Pieter,Brealey David,Brittain-Long Robin,Bulteel Naomi,Burden Tom,Burtenshaw Andrew,Caruth Vikki,Chadwick David,Chambler Duncan,Chee Nigel,Child Jenny,Chukkambotla Srikanth,Clark Tom,Collini Paul,Cosgrove Catherine,Cupitt Jason,Cutino-Moguel Maria-Teresa,Dark Paul,Dawson Chris,Dervisevic Samir,Donnison Phil,Douthwaite Sam,DuRand Ingrid,Dushianthan Ahilanadan,Dyer Tristan,Evans Cariad,Eziefula Chi,Fegan Chrisopher,Finn Adam,Fullerton Duncan,Garg Sanjeev,Garg Sanjeev,Garg Atul,Gkrania-Klotsas Effrossyni,Godden Jo,Goldsmith Arthur,Graham Clive,Hardy Elaine,Hartshorn Stuart,Harvey Daniel,Havalda Peter,Hawcutt Daniel B,Hobrok Maria,Hodgson Luke,Hormis Anil,Jacobs Michael,Jain Susan,Jennings Paul,Kaliappan Agilan,Kasipandian Vidya,Kegg Stephen,Kelsey Michael,Kendall Jason,Kerrison Caroline,Kerslake Ian,Koch Oliver,Koduri Gouri,Koshy George,Laha Shondipon,Laird Steven,Larkin Susan,Leiner Tamas,Lillie Patrick,Limb James,Linnett Vanessa,Little Jeff,MacMahon Michael,MacNaughton Emily,Mankregod Ravish,Masson Huw,Matovu Elijah,McCullough Katherine,McEwen Ruth,Meda Manjula,Mills Gary,Minton Jane,Mirfenderesky Mariyam,Mohandas Kavya,Mok Quen,Moon James,Moore Elinoor,Morgan Patrick,Morris Craig,Mortimore Katherine,Moses Samuel,Mpenge Mbiye,Mulla Rohinton,Murphy Michael,Nagel Megan,Nagarajan Thapas,Nelson Mark,Otahal Igor,Pais Mark,Panchatsharam Selva,Paraiso Hassan,Patel Brij,Pattison Natalie,Pepperell Justin,Peters Mark,Phull Mandeep,Pintus Stefania,Pooni Jagtur,Post Frank,Price David,Prout Rachel,Rae Nikolas,Reschreiter Henrik,Reynolds Tim,Richardson Neil,Roberts Mark,Roberts Devender,Rose Alistair,Rousseau Guy,Ryan Brendan,Saluja Taranprit,Shah Aarti,Shanmuga Prad,Sharma Anil,Shawcross Anna,Sizer Jeremy,Shankar-Hari Manu,Smith Richard,Snelson Catherine,Spittle Nick,Staines Nikki,Stambach Tom,Stewart Richard,Subudhi Pradeep,Szakmany Tamas,Tatham Kate,Thomas Jo,Thompson Chris,Thompson Robert,Tridente Ascanio,Tupper-Carey Darell,Twagira Mary,Ustianowski Andrew,Vallotton Nick,Vincent-Smith Lisa,Visuvanathan Shico,Vuylsteke Alan,Waddy Sam,Wake Rachel,Walden Andrew,Welters Ingeborg,Whitehouse Tony,Whittaker Paul,Whittington Ashley,Wijesinghe Meme,Williams Martin,Wilson Lawrence,Wilson Sarah,Winchester Stephen,Wiselka Martin,Wolverson Adam,Wooton Daniel G,Workman Andrew,Yates Bryan,Young Peter

Funder

Medical Research Council

National Institute for Health Research

Publisher

Elsevier BV

Subject

Pulmonary and Respiratory Medicine

Reference34 articles.

1. Asthma and COVID-19: is asthma a risk factor for severe outcomes?;Johnston;Allergy,2020

2. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus;Wark;J Exp Med,2005

3. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study;Docherty;BMJ,2020

4. Factors associated with COVID-19-related using OpenSAFELY;Williamson;Nature,2020

5. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy;Grasselli;JAMA,2020

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