Influence of virus strain, challenge dose, and time of therapy initiation on the in vivo influenza inhibitory effects of RWJ-270201

Author:

Sidwell Robert W,Smee Donald F,Huffman John H,Barnard Dale L,Morrey John D,Bailey Kevin W,Feng W.-C,Babu Y.S,Bush Karen

Publisher

Elsevier BV

Subject

Virology,Pharmacology

Reference9 articles.

1. BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design;Babu;J. Med. Chem.,2000

2. Comparison of the antiinfluenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir;Bantia;Antimicrob. Agents Chemother.,2001

3. Anti-influenza A activity of combination of amantadine and ribavirin in ferret tracheal ciliated epithelium;Burlington;J. Antimicrob. Chemother.,1983

4. Hayden, F.G., Treanor, J., Qu, R., Fowler, C., 2000. Safety and efficacy of an oral neuraminidase inhibitor RWJ-270201 in treating experimental influenza A and B in healthy adult volunteers. Poster presented at the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 17–20, 2000; Toronto, Canada. Abstract no. 1156.

5. Activity of selenazofurin against influenza A and B virus infections in mice;Sidwell;Antiviral Res.,1985

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