Ruxolitinib attenuates intimal hyperplasia via inhibiting JAK2/STAT3 signaling pathway activation induced by PDGF-BB in vascular smooth muscle cells

Author:

Song Hong-tao,Cui Yuan,Zhang Li-li,Cao Guang,Li Lin,Li Gang,Jia Xin-ju

Funder

National Natural Science Foundation of China

Hebei Medical Science Research Project

Publisher

Elsevier BV

Subject

Cell Biology,Cardiology and Cardiovascular Medicine,Biochemistry

Reference34 articles.

1. Cell cycle-dependent regulation of smooth muscle cell activation;Braun-Dullaeus;Arterioscler. Thromb. Vasc. Biol.,2004

2. Vascular smooth muscle cell in atherosclerosis;Chistiakov;Acta Physiol (Oxford),2015

3. Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children;Frémond;J. Allergy Clin. Immunol.,2016

4. PDGF-BB carried by endothelial cell-derived extracellular vesicles reduces vascular smooth muscle cell apoptosis in diabetes;Gabriele;Diabetes,2018

5. Biointerface topography regulates phenotypic switching and cell apoptosis in vascular smooth muscle cells;Han;Biochem. Biophys. Res. Commun.,2020

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