N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents

Author:

Khelifi Ilhem,Naret Timothée,Hamze AbdallahORCID,Bignon Jérome,Levaique Hélène,Garcia Alvarez Maria Concepcion,Dubois Joëlle,Provot OlivierORCID,Alami MouadORCID

Funder

CNRS

University Paris-Sud

La Ligue Contre le Cancer

ANR

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference39 articles.

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3. Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin;Lin;Biochemistry,1989

4. A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin A-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer;Dowlati;Cancer Res.,2002

5. Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results;Rustin;J. Clin. Oncol.,2003

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