Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation-Reference-Cited by-同舟云学术

Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation

Published:2019-02 Issue: Volume:164 Page:317-333
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Shao Jingwei,Zhu Kongkai,Du Daohai,Zhang Yuanyuan,Tao Hongrui,Chen Zhifeng,Jiang Hualiang,Chen Kaixian,Luo Cheng^ORCID,Duan Wenhu

Funder

Ministry of Science and Technology of China

National Science and Technology Major Project

National Natural Science Foundation of China

Shandong Provincial Natural Science Foundation

K.C. Wong Education Foundation and Chinese Academy of Sciences

Science and Technology Commission of Shanghai Municipality

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference38 articles.

1. Protein arginine methylation of non-histone proteins and its role in diseases;Wei;Cell Cycle,2014

2. Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations;Ji;Chem. Biol. Drug Des.,2017

3. Arginine methylation: the coming of age;Blanc;Mol. Cell.,2017

4. The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity;Pollack;J. Biol. Chem.,1999

5. RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity;Guderian;J. Biol. Chem.,2010

Cited by 20 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Tetrahydroisoquinoline reduces angiogenesis by interacting myeloma cells with HUVECs mediated by extracellular vesicles;Medical Oncology;2024-08-05

2. Structure-based discovery of potent CARM1 inhibitors for colorectal cancer therapy;European Journal of Medicinal Chemistry;2024-04

3. Small molecules targeting selected histone methyltransferases (HMTs) for cancer treatment: Current progress and novel strategies;European Journal of Medicinal Chemistry;2024-01

4. Correction to “Simplified Derivatives of Tetrandrine as Potent and Specific P-gp Inhibitors to Reverse Multidrug Resistance in Cancer Chemotherapy”;Journal of Medicinal Chemistry;2023-10-20

5. Discovery of tetrahydroisoquinolineindole derivatives as first dual PRMT5 inhibitors/hnRNP E1 upregulators: Design, synthesis and biological evaluation;European Journal of Medicinal Chemistry;2023-10