Synthesis and biological evaluation of novel hybrids of highly potent and selective α4β2-Nicotinic acetylcholine receptor (nAChR) partial agonists-Reference-Cited by-同舟云学术

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Synthesis and biological evaluation of novel hybrids of highly potent and selective α4β2-Nicotinic acetylcholine receptor (nAChR) partial agonists

Published:2016-11 Issue: Volume:124 Page:689-697
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Zhang Han-Kun,Eaton J. Brek,Fedolak Allison,Gunosewoyo Hendra,Onajole Oluseye K.,Brunner Dani,Lukas Ronald J.,Yu Li-Fang,Kozikowski Alan P.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference24 articles.

1. Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system;Taly;Nat. Rev. Drug Discov.,2009

2. Varenicline: an alpha 4 beta 2 nicotinic receptor partial agonist for smoking cessation;Coe;J. Med. Chem.,2005

3. Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine;Picciotto;Nature,1998

4. Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization;Tapper;Science,2004

5. Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis;Mineur;Trends Pharmacol. Sci.,2010

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