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Identify liver X receptor β modulator building blocks by developing a fluorescence polarization-based competition assay

  • Published:2019-09 Issue: Volume:178 Page:458-467
  • ISSN:0223-5234
  • Container-title:European Journal of Medicinal Chemistry
  • language:en
  • Short-container-title:European Journal of Medicinal Chemistry

Author:

Zhang Zizhen,Chen Hao,Chen Ziyang,Ding Peng,Ju Yingchen,Gu QiongORCID,Xu Jun,Zhou Huihao

Funder

National Center for Protein Sciences Shanghai (NCPSS)

Shanghai Synchrotron Radiation Facility

National Natural Science Foundation of China

Guangdong Natural Science Foundation

Program for Guangdong Introducing Innovative and Entrepreneurial Teams

National Key Research and Development Program

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference52 articles.

1. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha;Janowski;Nature,1996

2. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway;Lehmann;J. Biol. Chem.,1997

3. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors;Joseph;Nat. Med.,2003

4. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha;Peet;Cell,1998

5. Liver X receptors (LXRs). Part I: structure, function,regulation of activity, and role in lipid metabolism;Wójcicka;Postepy Hig. Med. Dosw.,2007

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