Discovery of carbazole derivatives as novel allosteric MEK inhibitors by pharmacophore modeling and virtual screening-Reference-Cited by-同舟云学术

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Discovery of carbazole derivatives as novel allosteric MEK inhibitors by pharmacophore modeling and virtual screening

Published:2019-09 Issue: Volume:178 Page:802-817
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Xi Dandan,Niu Yan^ORCID,Li Hongyue^ORCID,Noha Stefan M.,Temml Veronika,Schuster Daniela,Wang Chao^ORCID,Xu Fengrong,Xu Ping

Funder

National Natural Science Foundation of China

Beijing Municipal Natural Science Foundation

Austrian Agency for International Mobility and Cooperation in Education, Science and Research (ÖAD)

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference50 articles.

1. Mitogen-activated protein kinase pathways;Robinson;Curr. Opin. Cell Biol.,1997

2. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases;Cargnello;Microbiol. Mol. Biol. Rev.,2011

3. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance;McCubrey;Biochim. Biophys. Acta,2007

4. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer;Roberts;Oncogene,2007

5. Mutations of the BRAF gene in human cancer;Davies;Nature,2002

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