Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design-Reference-Cited by-同舟云学术

Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design

Published:2021-12 Issue: Volume:226 Page:113819
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Van Manh Nguyen^ORCID,Hoang Van-Hai,Ngo Van T.H.^ORCID,Ann Jihyae,Jang Tae-ho,Ha Jung-Hye,Song Jae Young,Ha Hee-Jin,Kim Hee,Kim Young-Ho,Lee Jiyoun,Lee Jeewoo^ORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference68 articles.

1. The amyloid hypothesis of alzheimer's disease: progress and problems on the road to therapeutics;Hardy;Science,2002

2. Alzheimer's disease drug development pipeline;Cummings;2020, Alzheimer's Dement.,2020

3. Clinical trials of new drugs for alzheimer disease;Huang;J. Biomed. Sci.,2020

4. Anti-amyloid failures stack up as alzheimer antibody flops;Mullard;Nat. Rev. Drug Discov.,2019

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