Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity

Author:

Relitti NicolaORCID,Federico StefanoORCID,Pozzetti LucaORCID,Butini StefaniaORCID,Lamponi StefaniaORCID,Taramelli Donatella,D’Alessandro Sarah,Martin Rowena E.ORCID,Shafik Sarah H.ORCID,Summers Robert L.,Babij Simone K.,Habluetzel Annette,Tapanelli SofiaORCID,Caldelari RetoORCID,Gemma SandraORCID,Campiani Giuseppe

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference49 articles.

1. World Malaria Report 2019, Geneva;World Health Organization,2019

2. Geographic expansion of artemisinin resistance;Müller;J. Trav. Med.,2019

3. Combating malaria in africa;Trape;Trends Parasitol.,2002

4. Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities;Pulcini;Sci. Rep.,2015

5. Reversal of chloroquine resistance in Plasmodium falciparum by verapamil;Martin;Science,1987

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