Development of MDM2 degraders based on ligands derived from Ugi reactions: Lessons and discoveries
Author:
Funder
National Institutes of Health
National Cancer Institute
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference44 articles.
1. Protacs: chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation;Sakamoto;Proc. Natl. Acad. Sci. Unit. States Am.,2001
2. Targeting the von Hippel–Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction;Buckley;J. Am. Chem. Soc.,2012
3. Phthalimide conjugation as a strategy for in vivo target protein degradation;Winter;Science,2015
4. Protein knockdown using methyl Bestatin−Ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins;Itoh;J. Am. Chem. Soc.,2010
5. MDM2-Recruiting PROTAC offers superior, synergistic antiproliferative activity via simultaneous degradation of BRD4 and stabilization of p53;Hines;Canc. Res.,2019
Cited by 42 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Small-Molecule Approaches to Target Transcription Factors;Annual Review of Cancer Biology;2024-06-12
2. An overview of PROTACs targeting MDM2 as a novel approach for cancer therapy;European Journal of Medicinal Chemistry;2024-06
3. Targeting the undruggables—the power of protein degraders;Science Bulletin;2024-06
4. p53/MDM2 signaling pathway in aging, senescence and tumorigenesis;Seminars in Cancer Biology;2024-06
5. MDM2 Inhibitors for Cancer Therapy: The Past, Present, and Future;Pharmacological Reviews;2024-03-15
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3