Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides

Author:

McGuigan Christopher,Bourdin Claire,Derudas Marco,Hamon Nadège,Hinsinger Karen,Kandil Sahar,Madela Karolina,Meneghesso Silvia,Pertusati Fabrizio,Serpi Michaela,Slusarczyk Magdalena,Chamberlain Stanley,Kolykhalov Alexander,Vernachio John,Vanpouille Christophe,Introini Andrea,Margolis Leonid,Balzarini Jan

Funder

Inhibitex

KU Leuven

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference26 articles.

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2. Antiviral drugs in current clinical use;De Clercq;J. Clin. Virol.,2004

3. Pronucleotides: toward the in vivo delivery of antiviral and anticancer nucleotides;Wagner;Med. Res. Rev.,2000

4. Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89;Faletto;Antimicrob. Agents Chemother.,1997

5. In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver;Rashidi;Drug Metab. Dispos,1997

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