A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: Synthesis, biological evaluation, and molecular modeling-Reference-Cited by-同舟云学术

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A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: Synthesis, biological evaluation, and molecular modeling

Published:2019-11 Issue: Volume:182 Page:111672
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Zhang Bingbing,Liu Jiami,Gao Dingding,Yu Xiaolin,Wang Jinlei,Lei Xinsheng

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference72 articles.

1. Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

2. Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

3. Inside HDACs with more selective HDAC inhibitors

4. Selective histone deacetylase small molecule inhibitors: recent progress and perspectives

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1. Palladium-Catalyzed Defluorinative Alkylation of gem-Difluoroalkenes with Cyclopropanols: Stereoselective Synthesis of γ-Fluorinated γ,δ-Unsaturated Ketones;Organic Letters;2024-04-25

2. The Aldol Reaction: Transition Metal Enolates;Reference Module in Chemistry, Molecular Sciences and Chemical Engineering;2024

3. The Impact of Fluorination on the Design of Histone Deacetylase Inhibitors;Molecules;2023-02-19

4. Application of a fluorine strategy in the lead optimization of betulinic acid to the discovery of potent CD73 inhibitors;Steroids;2022-12

5. Highly enantioselective amination of η3-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands;Mendeleev Communications;2022-09

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