Multicomponent Petasis reaction for the identification of pyrazine based multi-target directed anti-Alzheimer's agents: In-silico design, synthesis, and characterization

Author:

Madhav Hari,Abdel-Rahman Somaya A.,Hashmi Md Amiruddin,Rahman Md Ataur,Rehan Mohammad,Pal Kavita,Nayeem Shahid M.,Gabr Moustafa T.,Hoda NasimulORCID

Funder

University Grants Commission

Indian Council of Medical Research

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference57 articles.

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3. Hypothesis: tau pathology is an initiating factor in sporadic Alzheimer's disease;Arnsten;Alzheimer's Dementia,2021

4. History and progress of hypotheses and clinical trials for Alzheimer's disease;Liu;Signal Transduct. Targeted Ther.,2019

5. Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics;Madhav;RSC Med. Chem.,2022

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