UGT-dependent regioselective glucuronidation of ursodeoxycholic acid and obeticholic acid and selective transport of the consequent acyl glucuronides by OATP1B1 and 1B3-Reference-Cited by-同舟云学术

UGT-dependent regioselective glucuronidation of ursodeoxycholic acid and obeticholic acid and selective transport of the consequent acyl glucuronides by OATP1B1 and 1B3

Published:2019-09 Issue: Volume:310 Page:108745
ISSN:0009-2797
Container-title:Chemico-Biological Interactions
language:en
Short-container-title:Chemico-Biological Interactions

Author:

Zhou Dandan,Kong Linghua,Jiang Yiguo,Wang Cheng,Ni Yao,Wang Yedong,Zhang Hongjian,Ruan Jianqing

Funder

US FDA

National Natural Science Foundation of China

Jiangsu Province Science Foundation for Youths

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference47 articles.

1. From a choleretic to an immunomodulator: historical review of ursodeoxycholic acid as a medicament;Makino;J. Gastroenterol. Hepatol.,1998

2. Primary biliary cirrhosis;Talwalkar;The Lancet,2003

3. Primary biliary cirrhosis;Carey;Lancet,2015

4. A placebo-controlled trial of obeticholic acid in primary biliary cholangitis;Nevens;N. Engl. J. Med.,2016

5. Molecular mechanisms of ursodeoxycholic acid toxicity & side effects: ursodeoxycholic acid freezes regeneration & induces hibernation mode;Kotb;Int. J. Mol. Sci.,2012

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