Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction

Author:

Nirogi Ramakrishna,Palacharla Raghava Choudary,Mohammed Abdul Rasheed,Manoharan Arunkumar,Ponnamaneni Ranjith kumar,Bhyrapuneni Gopinadh

Funder

Suven Life Sciences Ltd

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference50 articles.

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3. Non-P450 mediated oxidative metabolism of xenobiotics in drug metabolizing enzymes: cytochrome P450 and other enzymes in drug discovery and development;Lee;FontisMedia SA,2003

4. Inactivation of cytochrome P4502B1 by the monoamine oxidase inhibitors R-(−)-deprenyl and clorgyline;Sharma;Drug Metab. Dispos.,1996

5. Formation of a metabolic intermediate complex of cytochrome P4502B1 by clorgyline;Sharma;Drug Metab. Dispos.,1996

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