The use of intramolecular isotope effects to distinguish between deprotonation and hydrogen atom abstraction mechanisms in cytochrome P-450- and peroxidase-catalyzed N-demethylation reactions.-Reference-Cited by-同舟云学术

The use of intramolecular isotope effects to distinguish between deprotonation and hydrogen atom abstraction mechanisms in cytochrome P-450- and peroxidase-catalyzed N-demethylation reactions.

Published:1983-12 Issue:23 Volume:258 Page:14445-14449
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Miwa G T,Walsh J S,Kedderis G L,Hollenberg P F

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference46 articles.

1. Drug Metabolism: Chemical and Biochemical Aspects;Testa,1976

2. Source of oxygen in cytochrome P-450 catalyzed carbinolamine formation

3. Hepatic microsomal N-dealkylation reaction. Molecular oxygen as the source of the oxygen atom

4. N-Demethylation reactions catalyzed by chloroperoxidase.

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