Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria.
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference14 articles.
1. Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis
2. Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase
3. Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP
4. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors
5. Pargyline Prevents MPTP-Induced Parkinsonism in Primates
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