The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen.
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference45 articles.
1. Human .alpha.-thrombin binding to nonpolymerized fibrin-sepharose: evidence for an anionic binding region
2. Anion-binding exosite of human .alpha.-thrombin and fibrin(ogen) recognition
3. Thrombin specificity with tripeptide chromogenic substrates: comparison of human and bovine thrombins with and without fibrinogen clotting activities.
4. Catalytic competence of human .alpha.- and .gamma.-thrombin in the activation of fibrinogen and factor XIII
5. The use of sequence-specific antibodies to identify a secondary binding site in thrombin.
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