Genotoxicity of phenacetin in the kidney and liver of Sprague-Dawley gpt delta transgenic rats in 26-week and 52-week repeated-dose studies

Author:

Kawamura Yuji,Hayashi Hiroyuki,Masumura Kenichi,Numazawa Satoshi,Nohmi Takehiko

Funder

Japan Health Science Foundation

Publisher

Elsevier BV

Subject

Toxicology

Reference35 articles.

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2. Dose selection for carcinogenicity studies of pharmaceuticals: systemic exposure to phenacetin at carcinogenic dosage in the rat;Bergman;Regul. Toxicol. Pharmacol,1998

3. Computer program for the analysis of mutational spectra: application to p53 mutations;Cariello;Carcinogenesis,1994

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5. CDER, 2005. Guidance for Industry on Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers. http://www.fda.gov/downloads/Drugs/Guidance/UCM078932. pdf.

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