PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats

Author:

Andersen Michael Aagaard,Wegener Karen Malene,Larsen Steen,Badolo Lassina,Smith Garrick Paul,Jeggo Ross,Jensen Poul Henning,Sotty Florence,Christensen Kenneth Vielsted,Thougaard Annemette

Funder

Kirsten Christensen

Danish Innovation Foundation for financial support

Publisher

Elsevier BV

Subject

Toxicology

Reference25 articles.

1. Bovine renal lipofuscinosis: prevalence, genetics and impact on milk production and weight at slaughter in Danish cattle;Agerholm;Acta Vet. Scand.,2009

2. Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs;Baptista;PLoS One,2013

3. LRRK2 kinase inhibitors of different structural classes induce abnormal accumulation of lamellar bodies in type II pneumocytes in non-human primates but are reversible and without pulmonary functional consequences;Baptista;Workflow and Study Design,2015

4. Associating in vitro target binding and in vivo CNS occupancy of serotonin reuptake inhibitors in rats: the role of free drug concentrations;Bundgaard;Xenobiotica,2012

5. Leucine-rich repeat kinase 2 (LRRK2) pharmacological inhibition abates α-Synuclein gene-induced neurodegeneration;Daher;J. Biol. Chem.,2015

Cited by 51 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3