Structure–activity relationships for the impact of selected isothiazol-3-one biocides on glutathione metabolism and glutathione reductase of the human liver cell line Hep G2

Author:

Arning Jürgen,Dringen Ralf,Schmidt Maike,Thiessen Anette,Stolte Stefan,Matzke Marianne,Bottin-Weber Ulrike,Caesar-Geertz Birgit,Jastorff Bernd,Ranke Johannes

Publisher

Elsevier BV

Subject

Toxicology

Reference31 articles.

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2. Studies of chemical selectivity of hapten, reactivity, and skin sensitization potency. 3. Synthesis and studies on the reactivity toward model nucleophiles of the 13C-labeled skin sensitizers, 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI);Alvarez-Sanchez;Chem. Res. Toxicol.,2003

3. Covalent binding of the 13C-labeled skin sensitizers 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI) to a model peptide and glutathione;Alvarez-Sanchez;Bioorg. Med. Chem. Lett.,2004

4. Arning, J., Matzke, M., Stolte, S, Nehen, F., Bottin-Weber, U., Böschen, A, Abdulkarim, S., Jastorff, B., Ranke, J. (submitted for publication). Analysing cytotoxic effects of selected isothiazol-3-one biocides using the “Toxic Ratio” concept and the “T-SAR” approach. Environ. Sci. Technol.

5. Inhibition of glutathione reductase by dinitrosyl-iron-dithiolate complex;Boese;J. Biol. Chem.,1997

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