Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment

Author:

Gibson Erin M.,Nagaraja Surya,Ocampo Alfonso,Tam Lydia T.,Wood Lauren S.,Pallegar Praveen N.,Greene Jacob J.,Geraghty Anna C.,Goldstein Andrea K.,Ni Lijun,Woo Pamelyn J.,Barres Ben A.,Liddelow Shane,Vogel Hannes,Monje Michelle

Funder

California Institute for Regenerative Medicine

Unravel Pediatric Cancer

McKenna Claire Foundation

Virginia and D.K. Ludwig Fund for Cancer Research

National Institutes of Neurological Disorders and Stroke

Stanford Medical Scientist Training Program

Stanford Neuroscience Institute

Stanford Maternal and Child Health Research Institute

Anne T. and Robert M. Bass Endowed Faculty Scholarship in Pediatric Cancer and Blood Diseases

Stanford CTSA

BioX Institute

McCormick Fellowship

Stanford MedScholars Program

Christopher and Dana Reeve Foundation

Novartis Institute for Biomedical Research

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

JPB Foundation

Cure Alzheimer's Fund

Glenn Foundation

Esther B. O’Keeffe Charitable Foundation

Australian National Health and Medical Research Council

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference70 articles.

1. Stem cell transplantation reverses chemotherapy-induced cognitive dysfunction;Acharya;Cancer Res.,2015

2. Astrocytic activation generates de novo neuronal potentiation and memory enhancement;Adamsky;Cell,2018

3. American Cancer Society (2016). Cancer treatment & survivorship facts & figures 2016-2017. https://www.cancer.org/research/cancer-facts-statistics/survivor-facts-figures.html.

4. Cognitive and academic outcome following cranial irradiation and chemotherapy in children: a longitudinal study;Anderson;Br. J. Cancer,2000

5. White matter fractional anisotropy correlates with speed of processing and motor speed in young childhood cancer survivors;Aukema;Int. J. Radiat. Oncol. Biol. Phys.,2009

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