Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity-Reference-Cited by-同舟云学术

Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity

Published:2024-08 Issue:16 Volume:187 Page:4373-4388.e15
ISSN:0092-8674
Container-title:Cell
language:en
Short-container-title:Cell

Author:

Cillo Anthony R.,Cardello Carly,Shan Feng,Karapetyan Lilit,Kunning Sheryl,Sander Cindy,Rush Elizabeth,Karunamurthy Arivarasan,Massa Ryan C.,Rohatgi Anjali,Workman Creg J.,Kirkwood John M.,Bruno Tullia C.,Vignali Dario A.A.

Funder

Medical Center, University of Pittsburgh

University of Pittsburgh

NIH

Bristol-Myers Squibb Co

Publisher

Elsevier BV

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2. LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity;Cell;2024-08

3. LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity;Cell;2024-08

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