Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding

Author:

Starr Tyler N.ORCID,Greaney Allison J.ORCID,Hilton Sarah K.ORCID,Ellis Daniel,Crawford Katharine H.D.ORCID,Dingens Adam S.ORCID,Navarro Mary Jane,Bowen John E.ORCID,Tortorici M. AlejandraORCID,Walls Alexandra C.ORCID,King Neil P.ORCID,Veesler David,Bloom Jesse D.ORCID

Funder

Damon Runyon Cancer Research Foundation

National Institute of General Medical Sciences

Fast Grants

Howard Hughes Medical Institute

Pew Charitable Trusts

Open Philanthropy Project

Burroughs Wellcome Fund

Washington Research Foundation

Bill and Melinda Gates Foundation

Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference142 articles.

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3. Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies;Baum;Science,2020

4. Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice;Becker;Proc. Natl. Acad. Sci. USA,2008

5. Cryptic transmission of SARS-CoV-2 in Washington State;Bedford;medRxiv,2020

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