Potent inhibition of human folylpolyglutamate synthetase by a phosphinic acid mimic of the tetrahedral reaction intermediate

Author:

McGuire John J.,Haile William H.,Valiaeva Nadya,Bartley David,Guo Jianxia,Coward James K.

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference25 articles.

1. IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN). Nomenclature and symbolism for amino acids and peptides. Recommendations 1983. Eur J Biochem 1984;138:9–37.

2. McGuire JJ, Coward JK. Pteroylpolyglutamates: biosynthesis, degradation, and function. In: Blakley RL, Benkovic SJ, editors. Folates and pterins. Chemistry and biochemistry of folates, vol. 1. New York: Wiley; 1984. p. 135–90.

3. McGuire JJ. Anticancer antifolates: current status and future directions. Curr Pharm Des, in press.

4. Cross-resistance studies of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines;McGuire;Leukemia,1993

5. Folylpolyglutamate synthetase inhibition and cytotoxic effects of methotrexate analogs containing 2,ω-diaminoalkanoic acids;McGuire;Biochem. Pharmacol.,1986

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