The effect of liquid-liquid extraction on metabolite detection and analysis using NMR spectroscopy in human synovial fluid

Author:

Jaggard Matthew K.J.,Boulangé Claire L.,Graça Gonçalo,Akhbari Pouya,Vaghela Uddhav,Bhattacharya Rajarshi,Williams Horace R.T.,Lindon John C.,Gupte Chinmay M.

Funder

NIHR Imperial Biomedical Research Centre

National Institute for Health and Care Research

Imperial College London

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference30 articles.

1. Can joint fluid metabolic profiling (or "metabonomics") reveal biomarkers for osteoarthritis and inflammatory joint disease?: A systematic review;Akhbari;Bone Jt. Res.,2020

2. Can metabolic profiling provide a new description of osteoarthritis and enable a personalised medicine approach?;Jaggard;Clin. Rheumatol.,2020

3. Changes in sulfation patterns of chondroitin sulfate in equine articular cartilage and synovial fluid in response to aging and osteoarthritis;Brown;Am. J. Vet. Res.,1998

4. I. Knott, M. Dieu, M. Burton, V. Lecomte, J. Remacle, M. Raes, Differential effects of interleukin-1 alpha and beta on the arachidonic acid cascade in human synovial cells and chondrocytes in culture, Agents Actions, 39(3–4), 1993, pp. 126–131.

5. Stage related metabolic profile of the synovial fluid in patients with acute flares of knee osteoarthritis;Bocsa;Med. Pharm. Rep.,2022

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