The amiodarone derivative 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015) opens large-conductance Ca2+-activated K+ channels and relaxes vascular smooth muscle
Author:
Publisher
Elsevier BV
Subject
Pharmacology
Reference33 articles.
1. The amiodarone derivative KB130015 [2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran] induces an Na+-dependent increase of [Ca2+] in ventricular myocytes;Bito;J. Pharmacol. Exp. Ther.,2006
2. Inhibition of G protein-coupled and ATP-sensitive potassium currents by 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015), an amiodarone derivate;Brandts;J. Pharmacol. Exp. Ther.,2004
3. Vasoregulation by the β1 subunit of the calcium-activated potassium channel;Brenner;Nature,2000
4. Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone;Carlsson;J. Med. Chem.,2002
5. The large conductance Ca2+-activated potassium channel (pSlo) of the cockroach Periplaneta americana: structure, localization in neurons and electrophysiology;Derst;Eur. J. Neurosci.,2003
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