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Ginsenoside Re reduces Aβ production by activating PPARγ to inhibit BACE1 in N2a/APP695 cells

  • Published:2016-12 Issue: Volume:793 Page:101-108
  • ISSN:0014-2999
  • Container-title:European Journal of Pharmacology
  • language:en
  • Short-container-title:European Journal of Pharmacology

Author:

Cao Guoqiong,Su Ping,Zhang Shuai,Guo Limin,Zhang Haijing,Liang Yuexia,Qin Chunxia,Zhang Wensheng

Funder

National Natural Science Foundation of China

Key New Drug Creation and Development Program of China

Publisher

Elsevier BV

Subject

Pharmacology

Reference38 articles.

1. NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42;Buggia-Prevot;J. Biol. Chem.,2008

2. Reductions in levels of the Alzheimer's amyloid peptide after oral administration of ginsenosides;Chen;FASEB J.,2006

3. Neuroprotection of ginsenoside Re in cerebral ischemia-reperfusion injury in rats. J ASIAN NAT;Chen;Prod. Res.,2008

4. Ginsenoside Rg1 attenuates β-amyloid generation via suppressing PPARγ-regulated BACE1 activity in N2a-APP695 cells;Chen;Eur. J. Pharmacol.,2012

5. Effects of Panax ginseng in neurodegenerative diseases;Cho;J. Ginseng Res.,2012

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