Substantial Energetic Improvement with Minimal Structural Perturbation in a High Affinity Mutant Antibody
Author:
Publisher
Elsevier BV
Subject
Molecular Biology,Structural Biology
Reference56 articles.
1. Structural studies of binding site tryptophan mutants in the high-affinity streptavidin–biotin complex;Freitag;J. Mol. Biol.,1998
2. X-ray crystallographic studies of streptavidin mutants binding to biotin;Freitag;Biomol. Eng.,1999
3. Kinetic and affinity limits on antibodies produced during immune responses;Foote;Proc. Natl Acad. Sci. USA,1995
4. CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range;Yang;J. Mol. Biol.,1995
5. Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site;Schier;J. Mol. Biol.,1996
Cited by 114 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Fluorescein-Based SynNotch Adaptors for Regulating Gene Expression Responses to Diverse Extracellular Cues;2024-06-12
2. Enhancing affinity of neutralizing SARS-CoV-2 nanobody through facile structure-guided mutations in CDRs;2024-05-13
3. Target-dependent RNA polymerase as universal platform for gene expression control in response to intracellular molecules;Nature Communications;2023-11-17
4. A Rapid Antibody Enhancement Platform in Saccharomyces cerevisiae Using an Improved, Diversifying CRISPR Base Editor;ACS Synthetic Biology;2023-10-24
5. Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction;Scientific Reports;2023-06-17
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3