Effective drug discovery in Chagas disease
Author:
Funder
National Institutes of Health
Wellcome Trust
Publisher
Elsevier BV
Subject
Infectious Diseases,Parasitology
Reference46 articles.
1. Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates;Padilla;Nat. Microbiol.,2022
2. Frequency variation and dose modification of benznidazole administration for the treatment of Trypanosoma cruzi infection in mice, dogs and non-human primates;Bustamante;bioRxiv,2023
3. Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure;Bustamante;PLoS Negl. Trop. Dis.,2022
4. A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease;Bustamante;Sci. Transl. Med.,2020
5. Delayed activation of T cells at the site of infection facilitates the establishment of Trypanosoma cruzi in both naive and immune hosts;Padilla;mSphere,2023
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1. Pass the boron: benzoxaboroles as antiparasite drugs;Trends in Parasitology;2024-09
2. The epidemiology of Chagas disease in the Americas;The Lancet Regional Health - Americas;2024-09
3. Activity of pyridyl-pyrazolone derivatives against Trypanosoma cruzi;Experimental Parasitology;2024-07
4. Serial ‘deep-sampling’ PCR of fragmented DNA reveals the wide range ofTrypanosoma cruziburden among chronically infected hosts and allows accurate monitoring of parasite load following treatment;2024-06-10
5. Structural investigation of Trypanosoma cruzi Akt-like kinase as drug target against Chagas disease;Scientific Reports;2024-05-02
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