Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus microphyllus leaves, protects against naproxen-induced gastrointestinal damage in rats

Author:

Nicolau Lucas A.D.,Carvalho Nathalia S.,Pacífico Dvison M.,Lucetti Larisse T.,Aragão Karoline S.,Véras Leiz M.C.,Souza Marcellus H.L.P.,Leite José R.S.A.,Medeiros Jand Venes R.

Funder

National Counsel of Technological and Scientific Development − CNPq (Brazil) and Research foundation for the State of Piauí − FAPEPI

Publisher

Elsevier BV

Subject

Pharmacology,General Medicine

Reference40 articles.

1. Mucosal damage induced by preferential COX-1 and COX-2 inhibitors: role of prostaglandins and inflammatory response;Villegas;Life Sci.,2004

2. Gastrointestinal ulcerations induced by anti-inflammatory drugs in rats;Beck;Arch. Toxicol.,1990

3. Protective effect of astaxanthin on naproxen-induced gastric antral ulceration in rats;Kim;Eur. J. Pharmacol.,2005

4. Role of oxygen-derived free radicals in the pathogenesis of gastric mucosal lesions in rats;Yoshikawa;J. Clin. Gastroenterol.,1990

5. Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process;Wallace;Am. J. Physiol.,1990

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