Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo

Author:

Cory Joseph G.,Cory Ann H.,Rappa Germana,Lorico Aurelio,Llu Mao-Chin,Lin Tai-Shun,Sartorelli Alan C.

Publisher

Elsevier BV

Subject

Cancer Research,Genetics,Molecular Biology,Molecular Medicine

Reference20 articles.

1. α-(N)-Formylheteroaromatic thiosemicarbazones. Inhibition of tumor-derived ribonucleoside diphosphate reductase and correlation with in vivo antitumor activity;French;J. Med. Chem.,1974

2. The chemistry and biological activity of α- (N-heterocyclic carboxaldehyde thiosemicarbazones;Agrawal;Prog. Med. Chem.,1978

3. The inhibition of ribonucleotide reductase by α-(N)-heterocyclic carboxaldehyde thiosemicarbazones;Moore,1989

4. Clinical trial of 5-hydroxypicolinaldehyde thiosemicarbazone (5-HP; NSC 107392), with special reference to its iron chelating properties;Krakoff;Cancer Chemother. Rep.,1974

5. Clinical and pharmacological studies with 5-hydroxy-2-formylpyridine thiosemicarbazone;Deconti;Cancer Res.,1972

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