Mcl-1 as a “barrier” in cancer treatment: Can we target it now?

Author:

Pervushin Nikolay V.,Senichkin Viacheslav V.,Zhivotovsky Boris,Kopeina Gelina S.

Publisher

Elsevier

Reference150 articles.

1. Mcl-1 is a potential therapeutic target in multiple types of cancer;Akgul;Cell. Mol. Life Sci.,2009

2. Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA;Albershardt;J. Biol. Chem.,2011

3. Preclinical evaluation of the simultaneous inhibition of MCL-1 and BCL-2 with the combination of S63845 and venetoclax in multiple myeloma;Algarín;Haematologica,2019

4. Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage;Arbour;J. Neurosci.,2008

5. A phase II, multicenter, open-label study of obatoclax mesylate in patients with previously untreated myelodysplastic syndromes with anemia or thrombocytopenia;Arellano;Clin. Lymphoma Myeloma Leuk.,2014

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