PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury

Author:

Wagner JosephinORCID,Park Lauren M.ORCID,Mukhopadhyay Partha,Matyas Csaba,Trojnar Eszter,Damadzic Ruslan,Jung Jeesun,Bell Andrew S.,Mavromatis Lucas A.,Hamandi Ali M.,Rosoff Daniel B.,Vendruscolo Leandro F.,Koob George F.,Pacher Pal,Lohoff Falk W.

Publisher

Elsevier BV

Reference58 articles.

1. Pretreatment with PCSK9 Inhibitor Protects the Brain Against Cardiac Ischemia/Reperfusion Injury Through a Reduction of Neuronal Inflammation and Amyloid Beta Aggregation;Apaijai;J Am Heart Assoc. Jan 22,2019

2. Arif M, Matyas C, Mukhopadhyay P, Yokus B, Trojnar E, Paloczi J, Paes-Leme B, Zhao S, Lohoff FW, Haskó G, Pacher P. Data-driven transcriptomics analysis identifies PCSK9 as a novel key regulator in liver aging. Geroscience. 2023 Oct;45(5):3059-3077. doi: 10.1007/s11357-023-00928-w. Epub 2023 Sep 20. PMID: 37726433; PMCID: PMC10643490.

3. Bajaj JS. Alcohol, liver disease and the gut microbiota. Nature Reviews Gastroenterology & Hepatology. 2019/04/01 2019;16(4):235-246. doi:10.1038/s41575-018-0099-1.

4. Bataller R, Cabezas J, Aller R, Ventura-Cots M, Abad J, Albillos A, Altamirano J, Arias-Loste MT, Bañares R, Caballería J, Caballería L, Carrión JA, Diago M, Fernández Rodríguez C, Gallego R, García-Cortes M, García-Monzón C, Genescà J, Ginés P, Hernandez-Guerra M, Jorquera F, Lligoña A, Molina E, Pareja MJ, Planas R, Tomé S, Salmerón J, Romero-Gómez M. Alcohol-related liver disease. Clinical practice guidelines. Consensus document sponsored by AEEH. Gastroenterol Hepatol. 2019 Dec;42(10):657-676. English, Spanish. doi: 10.1016/j.gastrohep.2019.09.006. Epub 2019 Nov 23. PMID: 31771785.

5. Bell AS, Rosoff DB, Mavromatis LA, Jung J, Wagner J, Lohoff FW. Comparing the Relationships of Genetically Proxied PCSK9 Inhibition with Mood Disorders, Cognition, and Dementia Between Men and Women: A Drug-Target Mendelian Randomization Study. J Am Heart Assoc. 2022 Nov;11(21): e026122. doi: 10.1161/JAHA.122.026122. Epub 2022 Oct 26. PMID: 36285785; PMCID: PMC9673626.

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